Aspirin → HCID 178475382, compound

HRID 2285739Notes

Reaction equation

HRID 2285739 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([NH:13][C:14]([NH2:16])=[NH:15])[CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].[C:17]([O:20][C:21]1[C:22](=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:23]([OH:25])=[O:24])(=[O:19])[CH3:18]>C(Cl)(Cl)Cl>[C:17]([O:20][C:21]1[C:22](=[CH:26][CH:27]=[CH:28][CH:29]=1)[C:23]([OH:25])=[O:24])(=[O:19])[CH3:18].[OH:1][C:2]1[CH:3]=[C:4]([NH:13][C:14]([NH2:16])=[NH:15])[CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

4

Reactant 2

HCID 2244AspirinHCID 1784690363-Hydroxy-4-carboethoxyphenylguanidine

Product 1

HCID 178475382HCID 178475382, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4.8 g of 3-hydroxy-4-carboethoxyphenylguanidine was suspended in 200 ml of chloroform, and 3.9 g of acetylsalicylic acid was added. The mixture was stirred at room temperature for 3 hours. After the reaction, the reaction mixture was cooled, and the resulting crystals were collected by filtration. The crystals were then recrystallized from a mixture of acetone and ligroin.

Workup

  1. customAfter the reaction
  2. temperaturethe reaction mixture was cooled
  3. filtrationthe resulting crystals were collected by filtration
  4. customThe crystals were then recrystallized from a mixture of acetone and ligroin

Sources & evidence

ORD record
ord-8a02a65f99b142e19f40468e49499326
Source dataset
uspto-grants-1982_04
Patent number
US04324801

Reaction notes

Loading…