Sodium Phosphate, Dibasic → HCID 20544241, compound

HRID 2285742Notes

Reaction equation

HRID 2285742 reaction equation
FC(F)(F)C(OO)=[O:4].[C:9]1([CH2:15][CH2:16][CH2:17][C:18](=[CH2:22])[C:19]([OH:21])=[O:20])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.P([O-])([O-])(O)=O.[Na+].[Na+]>C(Cl)Cl>[C:9]1([CH2:15][CH2:16][CH2:17][C:18]2([C:19]([OH:21])=[O:20])[CH2:22][O:4]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 24203Sodium Phosphate, DibasicHCID 10290812Trifluoroperacetic acidHCID 12932122HCID 12932122, compound

Product 1

HCID 20544241HCID 20544241, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Alternatively, the compound is obtained as follows: a solution of trifluoroperacetic acid (prepared from 1.8 ml of 85% strength hydrogen peroxide, 17 g of trifluoroacetic anhydride and 15 ml of methylene chloride) is added dropwise to a boiling mixture of 9.5 g of 5-phenyl-2-methylenevaleric acid and 28 g of disodium hydrogen phosphate in 50 ml of methylene chloride. The mixture is boiled under reflux for a further 30 minutes; 150 ml of ice-water are added; *the organic phase is separated off and, after drying over sodium sulfate, is concentrated. The title compound remains as a viscous oil.

Workup

  1. customAlternatively, the compound is obtained
  2. temperatureunder reflux for a further 30 minutes
  3. custom*the organic phase is separated off
  4. dry with materialafter drying over sodium sulfate
  5. concentrationis concentrated

Sources & evidence

ORD record
ord-30d3de0805724287bfb0c687f2414727
Source dataset
uspto-grants-1982_04
Patent number
US04324796

Reaction notes

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