反应详情

The 4-fluorobenzylmalonic acid is heated to 170° to 175° for 1.5 hours. After cooling, the reaction product is stirred with a little diethyl ether. 41.6 g of 3-(4-fluorophenyl)propionic acid of m.p. 85° to 88° [from ethyl acetate/petroleum ether (1:4)] thereby crystallize out.

1. temperatureAfter cooling
2. custom41.6 g of 3-(4-fluorophenyl)propionic acid of m.p. 85° to 88° [from ethyl acetate/petroleum ether (1:4)] thereby crystallize out