Hydrochloric Acid → HCID 20537177, compound

Participants

Reaction Steps

25 g of 5-(4-chlorophenyl)-2-methylenevaleric acid ethyl ester, 100 ml of a 2 N sodium hydroxide solution and 50 ml of ethanol are stirred at 50° for 3 hours. After cooling, 100 ml of 2 N hydrochloric acid are added slowly, while cooling with ice, to the reaction mixture which is then extracted 4 times, with 50 ml of diethyl ether each time. The united organic phases are washed with water, dried over sodium sulfate and concentrated. 20.5 g of 5-(4-chlorophenyl)-2-methylenevaleric acid remain as a brown oil.

Provenance & Evidence