反应详情

温度

120 °C

To 41.0 g. (0.12 mole) of α-(1-cyclohexyl-3-azetidinyl)-α,α-diphenylacetonitrile was added 100 g. of a 70% solution of sulfuric acid, and the mixture was stirred and heated at 120° C. for 48 hrs. The solution was then poured over ice and made basic with 50% sodium hydroxide, and extracted with chloroform. The organic layer was dried, filtered, and concentrated in vacuo. The residue was crystallized twice from isopropyl ether, the crystallized material weighed 8.0 g. (20% yield) and melted at 129°-131° C.

1. additionThe solution was then poured over ice
2. extractionextracted with chloroform
3. customThe organic layer was dried
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue was crystallized twice from isopropyl ether