Morpholine → HCID 13146125, compound

HRID 2285786Notes

Reaction equation

HRID 2285786 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH3:12])=[C:4]([NH2:13])[N:3]=1.[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>O>[N:14]1([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([CH3:12])=[C:4]([NH2:13])[N:3]=2)[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2898461-bromo-4-methylisoquinolin-3-amine

Product 1

HCID 13146125HCID 13146125, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 12 g (0.051 mole) of 1-bromo-3-amino-4-methylisoquinoline and 120 ml of morpholine is refluxed for 6 hours, then diluted with water. 8.5 g (83%) of 1-morpholinyl-3-amino-4-methylisoquinoline are obtained.

Workup

  1. temperatureis refluxed for 6 hours

Sources & evidence

ORD record
ord-e565982abc9147f28a04dcce2249d14a
Source dataset
uspto-grants-1982_04
Patent number
US04324894

Reaction notes

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