Acetic Acid → HCID 12879152, compound

HRID 2285791Notes

Reaction equation

HRID 2285791 reaction equation
FC1C=C(C=CC=1)[O:5][CH:6](OC1C=CC=C(F)C=1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)[N:8]=1.C(O)(=O)C>O>[F:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[O:13][C:9]1[N:8]=[C:7]([CH:6]=[O:5])[CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 12833257HCID 12833257, compound

Product 1

HCID 12879152HCID 12879152, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

A solution of 2.5 g (0.0059 m) of 2-[bis-(3-fluorophenoxy)methyl]-6-(3-fluorophenoxy)pyridine and 20 ml of 80 percent acetic acid was heated, with stirring, at 150° C. overnight. The reaction mixture was cooled, diluted with water and extracted with methylene chloride. The extract was washed with water and concentrated under reduced pressure. The desired 6-(3-fluorophenoxy)picolinaldehyde which melted at 42°-43° C.

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with methylene chloride
  3. washThe extract was washed with water
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-90127bec4b764e3abc8c2450e074e620
Source dataset
uspto-grants-1982_04
Patent number
US04324896

Reaction notes

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