Hydrochloric Acid → HCID 12818612, compound

Participants

Reaction Steps

A stirred mixture of 5.3 g. (0.019 mole) of 4-chloro-1,7-dimethyl-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester, 1.9 g. (0.019 mole) of N-methylpiperazine and 1.9 g. (0.019 mole) of sodium carbonate in 100 ml. of ethanol was heated under reflux for 5 hours. The mixture was filtered and the filtrate was evaporated in a rotary evaporator. The residue was triturated with 150 ml. of 10% aqueous sodium carbonate and was extracted with 150 ml. of ether. The ether layer was dried over magnesium sulfate, filtered and was diluted with 30 ml. of ethanol. This solution was acidified with an ethereal hydrochloric acid solution. The precipitate which formed was collected and was recrystallized from ethanol to afford 1.0 g. of product as the hydrochloride, hemihydrate, m.p. 278°-280° C. dec.

Provenance & Evidence