HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propyl-6-amino-5-nitrosouracil → 5,6-Diamino-1-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propyl-6-amino-5-nitrosouracil | HCID 10703093 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-Diamino-1-propyl-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 10631341 | — |
Reaction Steps
33.3 g of 6-amino-5-nitroso-1-propyl-2,4-(1H,3H)-pyrimidinedione (III) was catalytically hydrogenated in 800 ml of DMF in the presence of 0.1 g PtO2 for 3 hours at room temperature and at a pressure of 200 kPa. The catalyst and the crystals were filtered off and washed with ethanol. Yield 29 g (93%) (IV).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04325956 |
| Source dataset | uspto-grants-1982_04 |
| ORD ID | ord-c0375d95cc2a40b79830237a0b534240 |
| Source note | uspto-grants-1982_04 |