Cyanoacetic acid → 6-Amino-1-butyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

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Reaction Conditions

Reaction Steps

To a solution of 46 g (0.55 mol) cyanoacetic acid and 100 ml of acetic anhydride was added 58 g (0.5 mol) of n-butylurea. The solution was stirred at 70° C. for 2 hours. After cooling white crystals were filtered off and washed with ethanol. Yield 68 g (74% (VII). This was stirred in 500 ml of water and 20 ml of 5 N NaOH was added in portions so the solution the whole time was basic. The reaction mixture was refluxed for 20 minutes and then neutralized with 5 N HCl. After cooling, white crystals were filtered off. Yield 50.6 g (75%) (VIII), NMR.

Provenance & Evidence