反应详情

A solution of 1-methyl-4-(4-nitrophenoxy)-4-phenylpiperidine (4.4 g, 14.1 mM) in methanol (250 ml) was hydrogenated at 1 atmosphere and ambient temperature over 5% palladium on charcoal (500 mg) until the theoretical uptake of hydrogen had occurred (about 2 hours). The catalyst was removed by filtration and the solvent evaporated under reduced pressure. Recrystallisation of the residue from IPA gave the title compound (2 g) m.p. 174°-5°.

1. custom(about 2 hours)
2. customThe catalyst was removed by filtration
3. customthe solvent evaporated under reduced pressure
4. customRecrystallisation of the residue from IPA