2-Hydrazinopyridine → HCID 54144898, compound

HRID 2285972Notes

Reaction equation

HRID 2285972 reaction equation
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][CH:6]([C:10](=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:7]([CH3:9])=O)[CH3:2].[NH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[NH2:20]>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[C:7]([CH3:9])=[N:20][N:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH3:2]

Participants

4

Reactant 2

HCID 786452-HydrazinopyridineHCID 53811318HCID 53811318, compound

Product 1

HCID 54144898HCID 54144898, compoundYield 64.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6.0 grams 3-benzoyl-levulinic acid ethyl ester, 2.7 grams 2-hydrazino-pyridine and 25 milliliters glacial acetic acid were mixed and the mixture was heated to the boiling temperature under reflux for 3 hours. The reaction mixture was worked up by a procedure analogous to that described above. 5.0 grams 3-methyl-5-phenyl-1-(2-pyridyl)-pyrazol-4-acetic acid ethyl ester, melting at 89°-90° C., were obtained, representing a yield of 64%.

Workup

  1. temperaturethe mixture was heated to the boiling temperature
  2. temperatureunder reflux for 3 hours

Sources & evidence

ORD record
ord-bd5b0ac0e5a74a2f8c2fb82f38b07efa
Source dataset
uspto-grants-1982_04
Patent number
US04325962

Reaction notes

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