Sulfuric Acid → 3,5-Dimethyl-1-phenyl-pyrazol-4-acetamide

Participants

Reaction Steps

10 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetonitrile were added to 40 milliliters concentrated sulfuric acid and the mixture was stirred over night at room temperature. The reaction mixture was poured into a mixture of ice and water and the pH was adjusted to 8 by the addition of aqueous sodium hydroxide. 6.8 grams 3,5-dimethyl-1-phenyl-pyrazol-4-acetamide, melting at 169°-170° C., were obtained, representing a yield of 63%.

Provenance & Evidence