Acetic Acid → HCID 20543148, compound

HRID 2286005Notes

Reaction equation

HRID 2286005 reaction equation
[NH2:1]/[C:2](/[CH3:7])=[CH:3]\[C:4](O)=[S:5].[C:8]1(=[O:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10](=O)[CH2:9]1.[C:19](O)(=O)[CH3:20].[C:23]1(C)C=CC=CC=1>>[CH3:7][C:2]1[NH:1][C:10]2[C:11]3[C:16]([C:8](=[O:18])[C:9]=2[CH2:23][C:3]=1[C:4]([CH2:19][CH3:20])=[S:5])=[CH:15][CH:14]=[CH:13][CH:12]=3

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 1140TolueneHCID 118151,3-IndandioneHCID 178464492HCID 178464492, compound

Product 1

HCID 20543148HCID 20543148, compound

Conditions

Temperature
0 °C

Procedure

2.98 g (0.02 mole) of S-ethyl ester of β-aminothiocrotonic acid, 2.92 g (0.02 mole) of indane-1,3-dione and 0.7 g of paraform are heated at reflux in 30 ml of toluene for 20 minutes under vigorous stirring in a flask provided with Dean-Starkpacking. There is distilled-off about 10 ml of the solvent; after cooling to a temperature of 0° C. 1.42 g (25%) a red substance is isolated which melts at 240° C. (from acetic acid).

Workup

  1. customprovided with Dean-Starkpacking

Sources & evidence

ORD record
ord-1f650474948143f1a003e1a048823ef2
Source dataset
uspto-grants-1982_04
Patent number
US04326064

Reaction notes

Loading…