Morpholine → Propanamide, N-[2-(4-morpholinyl)ethyl]-

HRID 2286010Notes

Reaction equation

HRID 2286010 reaction equation
[CH2:1]([C:3]1[O:4][CH2:5][CH2:6][N:7]=1)[CH3:2].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>C([O-])(=O)C.[Zn+2].C([O-])(=O)C>[N:8]1([CH2:5][CH2:6][NH:7][C:3](=[O:4])[CH2:1][CH3:2])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 664122-Ethyl-2-oxazoline

Product 1

HCID 5085484Propanamide, N-[2-(4-morpholinyl)ethyl]-Yield 83%

Reagents, catalysts & solvents 1

HCID 11192Zinc AcetateCatalyst

Procedure

Under the same conditions as Example 13, 2.5 gm (25 mmoles) of 2-ethyl-2-oxazoline, 2.2 gm (25 mmoles) of morpholine and 0.59 mg of zinc acetate are reacted to yield 83 percent N-(2-morpholinylethyl)propionamide.

Sources & evidence

ORD record
ord-f01bca3a68814746b0d9b8b396039293
Source dataset
uspto-grants-1982_04
Patent number
US04326067

Reaction notes

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