N,N-Dimethyl-1,3-propanediamine → N-(3'-Dimethylaminopropyl)-aspartic acid-4-cyclohexyl ester

Participants

Reaction Steps

In a manner analogous to that described in Example 1, 100 ml of triethylamine are added dropwise, with cooling, to 99.1 g (0.5 mol) of maleic acid-monocyclohexyl ester, and the mixture is reacted with 61.3 g (0.5 mol+20% excess) of 3-dimethylaminopropylamine for 1 hour at 80°-93° C. The reaction product is purified as described in Example 1 to yield 109.9 g (73.2% of theory) of the desired aspartic acid derivative having a melting point of 150°-152.5° C.

Provenance & Evidence