Potassium Chloride → HCID 12922713, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 84.3 g (0.3 mol) of 3-bromo-4-fluorobenzyl phenyl ether, 34.8 g (0.3 mol) of sodium phenolate, 7 g (0.11 mol) of copper powder, 10 g of potassium chloride and 50 ml of bis-(2-methoxyethyl) ether (diglyme) was heated to 160° C. for 5 hours, while stirring. The reaction batch was then cooled to 80° C., 300 ml of toluene were added and the mixture was filtered. The filtrate was washed once with 100 ml of 10% strength sodium sulphate and was then extracted twice by shaking with 300 ml of water each time. The organic phase was dried over magnesium sulphate and the solvent was stripped off under a water-pump vacuum. The oily residue was distilled in vacuo. 70.7 g (80.2% of theory) of 4-fluoro-3-phenoxy-benzyl phenyl ether with the boiling point 195°-197° C./3 mbars were obtained as a very viscous oil.

Provenance & Evidence