HCID 12593791, compound → HCID 13050369, compound

HRID 2286108Notes

Reaction equation

[F:1][CH:2]([F:9])[CH:3]1[NH:7][C:6](=[O:8])[CH2:5][CH2:4]1.FCC1NC(=[O:17])CC1>>[NH2:7][CH:3]([CH:2]([F:9])[F:1])[CH2:4][CH2:5][C:6]([OH:17])=[O:8]

Participants

Reactant 2

HCID 12593791HCID 12593791, compound

HCID 20543327HCID 20543327, compound

Product 1

HCID 13050369HCID 13050369, compound

Procedure

When in the procedure of Example 5 500 mg of 5-difluoromethyl-2-pyrrolidone is substituted for 5-fluoromethyl-2-pyrrolidone, 4-amino-4-difluoromethylbutyric acid is obtained.

Sources & evidence

ORD record: ord-c5505449e6484cf493ef10390428b917
Source dataset: uspto-grants-1982_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04326071

Reaction notes

Loading…