5-(Hydroxymethyl)pyrrolidin-2-one → 6-Oxo-piperidine-2-carbaldehyde

HRID 2286116Notes

Reaction equation

HRID 2286116 reaction equation
[OH:1][CH2:2][CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.OCC1NC(=O)CC1>>[CH:2]([CH:3]1[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1)=[O:1]

Participants

3

Reactant 2

HCID 5583595-(Hydroxymethyl)pyrrolidin-2-oneHCID 145063136-(Hydroxymethyl)piperidin-2-one

Product 1

HCID 199030706-Oxo-piperidine-2-carbaldehyde

Procedure

When in the procedure of Example 6 (A) an appropriate amount of 6-hydroxymethyl-2-piperidone is substituted for 5-hydroxymethyl-2-pyrrolidone, 6-formyl-2-piperidone is obtained. When an appropriate amount of 6-formyl-2-piperidone is substituted for 5-formyl-2-pyrrolidone in the procedure of Example 6 (B), 6-difluoromethyl-2-piperidone is obtained which, when substituted for 5-difluoromethyl-2-pyrrolidone in an appropriate amount in the procedure of Example 5, yields 5-amino-5-difluoromethylpentanoic acid.

Sources & evidence

ORD record
ord-fd32177042dd40cb93dfc3c6295309c8
Source dataset
uspto-grants-1982_04
Patent number
US04326071

Reaction notes

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