1,5-Diazabicyclo(4.3.0)non-5-ene → HCID 12881671, compound

Participants

Reaction Steps

A mixture of 5.9 g of 1-methyl-2-(2-bromoethyl)-4-(4-chlorophenyl)-1,2,4-triazolidin-3-one-5-thione (prepared as in Example 3) and 2.1 g 1,5-diaza-bicyclo[4.3.0] non-5-ene in 100 ml chloroform was heated to reflux for 3 hours and stirred overnight at room temperature. The mixture was washed with water, dried (MgSO4), stripped and chromatographed by high-pressure liquid chromatography. Yield: 2.6 g.

Provenance & Evidence