1-(1H-Imidazol-1-yl)ethanone → HCID 12832896, compound

HRID 2286129Notes

Reaction equation

HRID 2286129 reaction equation
[Cl:1][C:2]1[C:3]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=2)=[CH:4][NH:5][CH:6]=1.[C:17](N1C=CN=C1)(=[O:19])[CH3:18]>>[C:17]([N:5]1[CH:6]=[C:2]([Cl:1])[C:3]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:14])[F:15])[CH:8]=2)=[CH:4]1)(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 20541641HCID 20541641, compound

Product 1

HCID 12832896HCID 12832896, compoundYield 68.3%

Procedure

The mixture of 1 g of 4-chloro-3-(3-trifluoromethylphenyl)pyrol and 2 g of N-acetylimidazole was fused for 1.5 hours at 140°-150° C. The resulding reaction mixture was purified by silicagel chloromatography using 10% solution of aceton in n-hexane as solvent to obtain 0.8 g of the desired product (pale reddish brown crystal, m.p. 70°-71.5° C.).

Workup

  1. customThe resulding reaction mixture
  2. customwas purified by silicagel chloromatography

Sources & evidence

ORD record
ord-3786fb32c26d46d092a8320201f45b42
Source dataset
uspto-grants-1982_04
Patent number
US04326881

Reaction notes

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