1-(1H-Imidazol-1-yl)ethanone → HCID 12832897, compound

Participants

Reaction Steps

The mixture of 4.35 g of 3-(2-chlorophenyl)-4-chloropyrol and 5.3 g of N-acetylimidazole was heated for 4 hours at 100° to 110° C. After cooling, the reaction mixture was dissolved in 200 ml of ether and the resulting ether solution was washed with successive, diluted hydrochloric acid and water. The ether solution was dried with anhydrous sodium sulfate and evaporated to dryness under reduced pressure. The residual crude product was purified by silicagel chromatography using mixed solvent of n-hexane and benzene (1:1) to obtain 2.5 g of the desired product (colorless crystal, m.p. 82°-84° C.).

Provenance & Evidence