1-(1H-Imidazol-1-yl)ethanone → HCID 12832898, compound

HRID 2286131Notes

Reaction equation

HRID 2286131 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([Cl:13])=[CH:11][NH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:14](N1C=CN=C1)(=[O:16])[CH3:15]>CCOCC.O>[C:14]([N:10]1[CH:11]=[C:12]([Cl:13])[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)=[CH:9]1)(=[O:16])[CH3:15]

Participants

5

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 20541639HCID 20541639, compound

Product 1

HCID 12832898HCID 12832898, compoundYield 57.8%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent2×

Procedure

The mixture of 6.5 g of 3-(3-chlorophenyl)-4-chloropyrol and 10.1 g of N-acetylimidazole was heated for one hour at 100°-110° C. After cooling, the reaction mixture was dissolved in a mixture of 200 ml of ether and 20 ml of water and the resulting ether solution was treated as in Example 4 to obtain 4.5 g of the desired product (colorless crystal, m.p. 88°-90° C.).

Workup

  1. temperaturewas heated for one hour at 100°-110° C
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-9b6a41b9e5e640b0994dd0370dcbc43a
Source dataset
uspto-grants-1982_04
Patent number
US04326881

Reaction notes

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