Methyl Isocyanate → (E)-Methomyl

Participants

Reaction Steps

A 256 g portion of an N-methyl pyrrolidone solution of methomyl oxime (containing 0.4 mole MMO) and 0.5 g triethylamine was charged to a 500 ml 5-necked flask. To this was added 28.7 g (0.5 mole) methyl isocyanate rapidly. The temperature rose to 40° C. for 1.0 hour. The reaction mixture was then transferred to a Kugelrohr apparatus, and the solvent removed at reduced pressure. A yield of 96% Methomyl, assaying >99% was realized.

Provenance & Evidence