Hydroxyamine hydrochloride → HCID 73682984, compound

Participants

Reaction Steps

A solution of 13.0 g (40.1 mmol) of 7-acetyl-1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one and 13.0 g of hydroxylamine hydrochloride in 65 ml of pyridine and 65 ml of ethanol is left to stand at room temperature for 4 hours. The mixture is taken up in methylene chloride, washed with 2 N hydrochloric acid and water, dried and evaporated. Traces of pyridine are removed by azeotropic evaporation with toluene. The residue gives, from methylene chloride/hexane, 1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-7-[1-(hydroxyimino)ethyl]-2H-1,4-benzodiazepin-2-one of melting point 236°-238°.

Provenance & Evidence