5-(o-fluorophenyl)-2,3-dihydro-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepine-7-diazonium tetrafluoroborate → 7-amino-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-2H-1,4-benzodiazepin-2-one

HRID 2286173Notes

Reaction equation

HRID 2286173 reaction equation
FC1C=CC=CC=1C1C2C=C(C(=NO)C)C=CC=2N(C)C(=O)C(C)N=1.F[B-](F)(F)F.[F:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[C:38]1[C:44]2[CH:45]=[C:46]([N+:49]#N)[CH:47]=[CH:48][C:43]=2[NH:42][C:41](=[O:51])[C:40]([CH3:53])([CH3:52])[N:39]=1>>[NH2:49][C:46]1[CH:47]=[CH:48][C:43]2[NH:42][C:41](=[O:51])[C:40]([CH3:53])([CH3:52])[N:39]=[C:38]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][C:32]=3[F:31])[C:44]=2[CH:45]=1

Participants

3

Reactant 2

HCID 205421005-(o-fluorophenyl)-2,3-dihydro-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepine-7-diazonium tetrafluoroborateHCID 736829855-(o-fluorophenyl)-1,3-dihydro-7-[1-(hydroxyimino)ethyl]-1,3-dimethyl-2H-1,4-benzodiazepin-2-one

Product 1

HCID 205420917-amino-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-2H-1,4-benzodiazepin-2-one

Procedure

From 56.62 g (0.19 mol) of 7-amino-5-(o-fluorophenyl)-1,3-dihydro-3,3-dimethyl-2H-1,4-benzodiazepin-2-one there is obtained in analogy to paragraph (e) of Example 1 5-(o-fluorophenyl)-2,3-dihydro-3,3-dimethyl-2-oxo-1H-1,4-benzodiazepine-7-diazonium tetrafluoroborate of melting point 203°.

Sources & evidence

ORD record
ord-19b76026096744f39ca99513e752e858
Source dataset
uspto-grants-1982_04
Patent number
US04327026

Reaction notes

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