HCID 86738350, compound → HCID 20542080, compound

Participants

Reaction Steps

2.5 g of Raney-nickel paste are added to a solution of 2.22 g (6.28 mmol) of 5-(o-fluorophenyl)-1,3-dihydro-7-[1-(hydroxyimino)ethyl]-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one in 100 ml of 2 N methanolic ammonia and the mixture is stirred at room temperature for 24 hours in a hydrogen atmosphere. The catalyst is filtered off and the solvent is concentrated in vacuo. After filtration over 50 g of silica gel using chloroform as the elution agent, the residue gives 7-(1-aminoethyl)-5-(o-fluorophenyl)-1,3-dihydro-1,3,3-trimethyl-2H-1,4-benzodiazepin-2-one as a foam of melting point 50°-51°.

Provenance & Evidence