Sodium Hydroxide → HCID 12795493, compound

HRID 2286207Notes

Reaction equation

HRID 2286207 reaction equation
[F:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][C:10]([F:16])=[C:11]([CH3:15])[C:12]=2[F:14])[C:7](=[O:17])[C:6]([C:18]([O:20]CC)=[O:19])=[CH:5]1.[OH-].[Na+]>C(O)C>[F:1][CH2:2][CH2:3][N:4]1[C:13]2[C:8](=[CH:9][C:10]([F:16])=[C:11]([CH3:15])[C:12]=2[F:14])[C:7](=[O:17])[C:6]([C:18]([OH:20])=[O:19])=[CH:5]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12795491HCID 12795491, compound

Product 1

HCID 12795493HCID 12795493, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.13 g of ethyl 1-(2-fluoroethyl)-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate are suspended in 50 ml of ethanol, and 50 ml of an aqueous 2% sodium hydroxide solution are added thereto. The suspension is stirred at room temperature for 3 hours. Then, the reaction mixture is evaporated under reduced pressure to remove solvent, and the residue is adjusted to about pH 1 with 10% hydrochloric acid. The crystalline precipitates are collected by filtration, washed with water and then dried. 2.85 g of 1-(2-fluoroethyl)-6,8-difluoro-7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid are thereby obtained as crystalline powder. Yield: 100%

Workup

  1. customThen, the reaction mixture is evaporated under reduced pressure
  2. customto remove solvent
  3. customThe crystalline precipitates
  4. filtrationare collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-69cdf9f9c213456781d04f425aa40f3c
Source dataset
uspto-grants-1982_04
Patent number
US04327101

Reaction notes

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