2-(Hydroxymethyl)-4-methylpentanoic acid → 4-Methyl-2-methylene valeric acid
Reaction equation
[CH3:1][CH:2]([CH3:10])[CH2:3][CH:4]([CH2:8]O)[C:5]([OH:7])=[O:6]>P(=O)(O)(O)O>[CH3:1][CH:2]([CH3:10])[CH2:3][C:4](=[CH2:8])[C:5]([OH:7])=[O:6]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 270 °C
Procedure
4-Methyl-2-(hydroxymethyl)pentanoic acid (8.7 g) is heated with 10 drops of 85% phosphoric acid in a Wood's metal bath at 220° C. for 20 minutes. A distillation head is attached and the pressure is slowly decreased to 60 mm while the temperature is increased to 270° C. Product starts to distill and the pressure is further decreased to 10 mm. The vapor temperature varies between 180° and 190° C. The yield of the title compound as distillate is 7.0 g.
Workup
- distillationto distill
- customThe vapor temperature varies between 180° and 190° C
Sources & evidence
- ORD record
- ord-b9b7168af8394689be2f630ef6d21ace
- Source dataset
- uspto-grants-1982_04
- Patent number
- US04327111
Reaction notes
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