Acetic Anhydride → HCID 13060845, compound

Participants

Reaction Steps

A mixture of 10.0 g. (0.044 m.) 4-(4-chlorophenyl)-2-mercaptothiazole (prepared by the reaction of α-bromo-4-chloroacetophenone with ammonium dithiocarbamate) and 10.0 g. (0.04 m.) α-bromophenylacetic acid in 200 ml. of acetone and 40 ml. each of glacial acetic acid and acetic anhydride is heated for 2 hours. After the solvents are removed, the residual solid is triturated with acetone and the resulting solid collected. 10 g. (58% yield) of the title product is obtained, m.p. 160°-165° C.

Provenance & Evidence