HCID 20542459, compound → HCID 20542458, compound

HRID 2286282Notes

Reaction equation

HRID 2286282 reaction equation
[N+:1]([CH2:4][CH:5]([OH:20])[CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=1)([O-])=O.[H][H]>[Ni]>[NH2:1][CH2:4][CH:5]([OH:20])[CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[CH:8]=1

Participants

4

Reactant 2

HCID 20542459HCID 20542459, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20542458HCID 20542458, compound

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

reducing the 3-nitro-1-phenyl-1-(m-chlorophenyl)propan-2-ol with hydrogen in the presence of Raney nickel to yield 3-amino-1-phenyl-1-(m-chlorophenyl)propan-2-ol or its salt and (c) dimethylating the 3-amino-1-phenyl-1(m-chlorophenyl)propan-2-ol or its salt to yield 3-dimethylamino-1-phenyl-1-(m-chlorophenyl)propan-2-ol or its salt.

Sources & evidence

ORD record
ord-a93345e2ecf1479392c9859381cd0317
Source dataset
uspto-grants-1982_04
Patent number
US04327228

Reaction notes

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