Hydrochloric Acid → HCID 131712708, compound

Participants

Reaction Steps

To a solution of 7-[2-methoxyimino-2-(2-formamidothiazol-4-yl)acetamido]-3-(4-methyl-1-piperazinyl)carbonyloxymethyl-3-cephem-4-carboxylic acid.trifluoroacetate (syn isomer)(1.0 g) in methanol (20 ml) was added conc.hydrochloric acid (0.62 ml) followed by stirring for 2 hours at ambient temperature. The reaction mixture was evaporated and the residue was pulverized in ethyl acetate, collected by filtration, washed with ethyl acetate and diethyl ether and then dried to give 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-(4-methyl-1-piperazinyl)carbonyloxymethyl-3-cephem-4-carboxylic acid.dihydrochloride (syn isomer).

Provenance & Evidence