Thiophenol → HCID 20542284, compound

Participants

Reaction Steps

A solution of 2.0 gm (0.036 mol) of sodium methylate in 50 ml of absolute methanol was admixed with 1.85 ml (0.018 mol) of thiophenol and 4.6 gm (0.015 mol) of 2-[2-(2-chloroethoxy)-4-methoxyphenyl]imidazo[4,5-b]pyridine hydrochloride. After refluxing for 4 hours, the reaction mixture was evaporated in vacuo, the residue was dissolved in water/methylene chloride, and the organic phase was separated and dried over magnesium sulfate. A pre-purification was carried out on 50 gm of silicagel with methylene chloride/acetone (100:0 to 80:20). The product was used in the next step without further purification.

Provenance & Evidence