Water → N-(2-Fluorosulfonylethyl)-N-ethyl-m-toluidine

Participants

Reaction Steps

N-Ethyl-m-toluidine (66.5 g) (0.5 m) is dissolved in isopropyl alcohol (75 ml) and vinylsulfonyl fluoride (55 g, 0.5 m) is added dropwise over 1.25 hr. The reaction exotherms to 38° C. and the reaction mixture is stirred for 1 hr. at ambient temperature and drowned into 500 ml of ice and water. The product is collected by filtration, washed with water, and dried in air. The product melts at 32°-34° C.

Provenance & Evidence