Methanol → HCID 70565434, compound

Participants

Reaction Steps

To a solution of 9-fluoro-11β-hydroxy-17-(methylthio)androsta-1,4,16-trien-3-one (100 mg) in a mixture of dry dichloromethane (10 ml) and methanol (8 ml) is added a 0.31 molar solution of chlorine in dichloromethane (1.0 ml). After a few hours, the solution is poured into a dilute sodium bicarbonate solution. The product is isolated by extraction with chloroform and the chloroform solution is washed with water, dried (anhydrous MgSO4) evaporated and the residue is purified by preparative thin layer chromatography to afford the title compound (35 mg), melting point 262°-268° C.

Provenance & Evidence