HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → (11beta)-16-Bromo-17-(ethylthio)-9-fluoro-11-hydroxyandrosta-1,4,16-trien-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 17-Ethylthio-9-fluoro-11beta-hydroxyandrosta-1,4,16-triene-3-one | HCID 12917712 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (11beta)-16-Bromo-17-(ethylthio)-9-fluoro-11-hydroxyandrosta-1,4,16-trien-3-one | HCID 70564041 | — |
Reaction Steps
A solution of (11β)-17-(ethylthio)-9-fluoro-11-hydroxyandrosta-1,4,16-trien-3-one (181 mg) in dichloromethane (10 ml) containing N-bromosuccinimide (98 mg) is stirred at room temperature for 2 hours and the reaction mixture is subjected to preparative thin layer chromatography on silica gel plates to isolate the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04265815 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-27f3471f9fb74aaea34c7e92b9764f08 |
| Source note | uspto-grants-1981_05 |