Acetic Anhydride → HCID 23463032, compound

HRID 2286341Notes

Reaction equation

HRID 2286341 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:12][C:11]2=[N:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:15][N:10]2[N:9]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[S:12][C:11]2=[N:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:15][N:10]2[N:9]=1)(=[O:24])[CH3:23]

Participants

3

Reactant 2

HCID 7918Acetic Anhydride2×HCID 135593893HCID 135593893, compound

Product 1

HCID 23463032HCID 23463032, compound

Procedure

4.6 g of 2-(2-hydroxyphenyl)-6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole (Example No. 28) are warmed to 150° C. in 75 ml of acetic anhydride for 1/2 an hour, excess acetic anhydride is evaporated off, the residue is stirred with water and the product is recrystallised from ethanol. 3.8 g, corresponding to 72% of theory, of colourless crystals of melting point 177° C. are obtained.

Workup

  1. customis evaporated off
  2. customthe product is recrystallised from ethanol
  3. custom3.8 g, corresponding to 72% of theory, of colourless crystals of melting point 177° C. are obtained

Sources & evidence

ORD record
ord-1a9938fa2fcd48849de683ea44231681
Source dataset
uspto-grants-1981_05
Patent number
US04265898

Reaction notes

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