N,N'-Dimethylurea → 4,8-Dimethyl-6,6-bis{[methyl(methylcarbamoyl)amino]methyl}-3,9-dioxo-2,4,8,10-tetraaza-6-phosphoniaundecane 4-methylbenzene-1-sulfonate

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Reaction Steps

Reaction of tetrakis(hydroxymethyl)phosphonium p-toluenesulfonate (16.31 g, 0.05 mol) with 1,3-dimethylurea (17.62 g, 0.2 mol) in toluene (200 ml), following Example 1, gave 27.21 g (89.7%) of tetrakis(1,3-dimethylureidomethyl)phosphonium p-toluenesulfonate (I, R=R'=CH3, R"=H, X=SO3C6H4CH3 -p) as a white, crystalline solid, mp 130°-131° C. after two recrystallizations from acetonitrile. The analytical sample was dried under vacuum for 2 hr at 100° C.

Provenance & Evidence