HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | n-(2,2-Dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide | HCID 13092500 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1,3-Dihydro-7,8-dimethoxy-2H-3-benzazepin-2-one | HCID 1482373 | — |
Reaction Steps
The acetamide (40 g.) was mixed with 200 ml. of concentrated hydrochloric acid and 200 ml. of glacial acetic acid and allowed to stand at room temperature overnight. The reaction mixture was poured into ice/water and the resulting solid was washed with water/methanol to give 2,3-dihydro-7,8-dimethoxy-2-oxo-1H-3-benzazepine, m.p. 239°-241° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04265890 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-4c194bab7eb645bcbaedd7f91cce9d1f |
| Source note | uspto-grants-1981_05 |