Nitric Acid → HCID 23462872, compound

HRID 2286400Notes

Reaction equation

HRID 2286400 reaction equation
S(=O)(=O)(O)O.[N+:6]([O-:9])(O)=[O:7].C([NH:13][C:14]1[C:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24][C:18]=2[C:17]([Cl:26])=[CH:16][CH:15]=1)(=O)C.[OH-].[Na+]>>[NH2:13][C:14]1[C:19]2[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24][C:18]=2[C:17]([Cl:26])=[CH:16][C:15]=1[N+:6]([O-:9])=[O:7]

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 23462861HCID 23462861, compound

Product 1

HCID 23462872HCID 23462872, compound

Procedure

To a stirred mixture of 200 g. of concentrated sulfuric acid and 50 g. of concentrated nitric acid at 0°-5° C. is added, in portions, 12.6 g. (0.05 mole) of 9-acetamido-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine. The solution is stirred at 0°-5° C. for 2 hours and then it is poured cautiously into 500 ml. of ice/water. The solution is made alkaline with sodium hydroxide. After being stirred at 25° C. for 16 hours, the mixture is filtered to give 9-amino-6-chloro-3-methyl-8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. additionTo a stirred mixture of 200 g
  2. additionit is poured cautiously into 500 ml
  3. stirringAfter being stirred at 25° C. for 16 hours
  4. filtrationthe mixture is filtered

Sources & evidence

ORD record
ord-0475ca576973416caa24537de4907e6d
Source dataset
uspto-grants-1981_05
Patent number
US04265890

Reaction notes

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