Ethylene Oxide → HCID 23462897, compound

HRID 2286411Notes

Reaction equation

HRID 2286411 reaction equation
[CH2:1]1[O:3][CH2:2]1.[CH3:4][O:5][C:6]1[C:16]([O:17][CH3:18])=[CH:15][C:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14][C:8]=2[C:7]=1[S:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>CO>[CH3:4][O:5][C:6]1[C:16]([O:17][CH3:18])=[CH:15][C:9]2[CH2:10][CH2:11][N:12]([CH2:1][CH2:2][OH:3])[CH2:13][CH2:14][C:8]=2[C:7]=1[S:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 6354Ethylene OxideHCID 23462864HCID 23462864, compound

Product 1

HCID 23462897HCID 23462897, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethylene oxide (0.5 ml., 0.44 g., 0.010 mole) is added to a stirred solution of 1.58 g. (0.005 mole) of 7,8-dimethoxy-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine in 100 ml. of methanol at 0° C. The mixture is stirred at this temperature for 2 hours and then allowed to warm to room temperature. Concentration of the mixture in vacuo gives 7,8-dimethoxy-3-(2-hydroxyethyl)-6-phenylthio-2,3,4,5-tetrahydro-1H-3-benzazepine.

Workup

  1. customat 0° C

Sources & evidence

ORD record
ord-aa870a02182445c48bea109872591ba7
Source dataset
uspto-grants-1981_05
Patent number
US04265890

Reaction notes

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