Water → HCID 23463334, compound

HRID 2286424Notes

Reaction equation

HRID 2286424 reaction equation
C(O[C:4](=[O:14])[CH2:5][C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.O.[F:16][C:17]([F:22])([F:21])[CH2:18][NH:19][NH2:20].O.N1C=CC(=O)N=1>C(O)(=O)C>[F:16][C:17]([F:22])([F:21])[CH2:18][N:19]1[C:4](=[O:14])[CH2:5][C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[N:20]1

Participants

6

Reactant 4

HCID 962WaterHCID 7170Ethyl benzoylacetateHCID 11513733PyrazoloneHCID 23463329HCID 23463329, compound

Product 1

HCID 23463334HCID 23463334, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

0.75 Mole (144 g) of benzoylacetic acid ethyl ester and 0.75 mole (126 g) of 2,2,2-trifluoroethylhydrazine hydrate were stirred for 3 hours in 900 ml of boiling acetic acid. The reaction mixture was poured out on 9 l of water. After 1 hour of stirring at room temperature the pyrazolone derivative was filtered and recrystallized from methanol.

Workup

  1. filtrationwas filtered
  2. customrecrystallized from methanol

Sources & evidence

ORD record
ord-beae53f3b24349c1ae2f4c5bbfa9c57a
Source dataset
uspto-grants-1981_05
Patent number
US04266014

Reaction notes

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