Benzyl chloroformate → HCID 12775797, compound

Participants

Reaction Steps

Benzyloxycarbonyl chloride was added dropwise to 3.7 kg of 1-amino-1-desoxy-D-glucitol (about 70% pure) in 7 liters of H2O, whilst stirring vigorously, and the pH was kept at 8-9 with 2 N sodium hydroxide solution. The batch was allowed to warm to 40°-50° C. during this operation. The batch was then further stirred overnight at room temperature and the precipitate was filtered off, washed with acetone and recrystallised from water.

Provenance & Evidence