HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoic Acid → 4-Fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoic Acid | HCID 9973 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Fluorobenzoyl chloride | HCID 67879 | — |
Reaction Steps
4-Fluorobenzoic acid, 14.0 g (0.1 mole) is refluxed for 30 minutes in 50 ml of thionyl chloride (SOCl2) and 1 drop of dimethylformamide (DMF). The thionyl chloride is removed under vacuum and azeotroped with 50 ml of benzene to give 4-fluorobenzoyl chloride as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04265905 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-2f64ca0b11d14909bc34351442f6a4fd |
| Source note | uspto-grants-1981_05 |