HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 23461659, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Amino-4-methylpiperazine | HCID 81349 | — |
| Reactant | 4-Acetamido-5-chloro-2-methoxybenzoyl chloride | HCID 11379992 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 23461659 | HCID 23461659 | 49.3% |
Reaction Steps
4-acetylamino-5-chloro-2-methoxy benzoyl chloride (2.70 g, 0.0103 mole) in anhydrous benzene (100 ml) in the presence of triethylamine (1.1 g) was treated with 4-methyl-1-amino piperazine (1.18 g). After 6 hours the reaction mixture was basified with dilute sodium hydroxide and extracted with hot ethyl acetate. On cooling the extracts yielded 4-acetylamino-5-chloro-2-methoxy-N-[4-methyl-1-piperazinyl]benzamide (1.72 g), m.p. 198°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267175 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-c0cc291bed034369b188fca0a3331003 |
| Source note | uspto-grants-1981_05 |