Tetrahydrofuran → 4-Ethylpiperazin-1-amine

Participants

Reaction Steps

A solution of N-ethyl-N'-nitroso piperazine (4.0 g, 0.028 mole) in anhydrous freshly distilled tetrahydrofuran (80 ml) was added dropwise to a stirred suspension of lithium aluminium hydride (1.5 g, excess) under nitrogen in anhydrous tetahydrofuran (160 ml) at 20°-25° C. After addition stirring was continued for a further 8 hours. Work up via controlled addition of water (1.5 ml), 10% sodium hydroxide (2.25 ml) and water (3.75 ml) gave N-amino-N'-ethyl piperazine (2.26 g, 63%) as a pale straw coloured oil.

Provenance & Evidence