Potassium Hydroxide → HCID 23461670, compound

Participants

Reaction Conditions

Reaction Steps

1-methylhomopiperazine (prepared as described by A. H. Sommers et al, in J. Amer. Chem. Soc. 76, 5805, 1954) (6.10 g, 0.0535 mole) was dissolved in concentrated hydrochloric acid (25 ml), cooled to 0°-5° C., stirred and treated dropwise with sodium nitrite (4.06 g) in water (10 ml). After addition the solution was allowed to come to room temperature, then heated for 1/2 hour at 70° C. The solution was cooled and basified with solid KOH and extracted with ether (3×100 ml). The dried (K2CO3) extracts yielded N-methyl-N'-nitrosohomopiperazine (3.80 g, 50%) as a pale yellow oil.

Provenance & Evidence