HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-acetylamino-5-chloro-2-methoxy-N-[4-(3-methylbutyl)-1-piperazinyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Acetamido-5-chloro-2-methoxybenzoyl chloride | HCID 11379992 | — |
| Reactant | 1-(3-Methylbutyl)-4-nitrosopiperazine | HCID 23461651 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-acetylamino-5-chloro-2-methoxy-N-[4-(3-methylbutyl)-1-piperazinyl]benzamide | HCID 23461655 | 56.6% |
Reaction Steps
N-(3-methyl-butyl)-N'-nitroso-piperazine (2.5 g.) was added to 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride (prepared from 3.5 g. of corresponding acid and thionylchloride) and triethylamine (5 ml.) in anhydrous toluene (250 ml.). After 1 hour, 10% sodium hydroxide (5 ml.) was added and the toluene layer separated, dried and evaporated to give 4-acetylamino-5-chloro-2-methoxy-N-[4-(3-methylbutyl)-1-piperazinyl]benzamide (3 g., 52%), m.p. 128°-30° (ex-ethylacetate/light petroleum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267175 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-f4484cc0a7684d558b20a8a8a1872326 |
| Source note | uspto-grants-1981_05 |