HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → HCID 70575136, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Amino-4-methylpiperazine | HCID 81349 | — |
| Reactant | HCID 23461675 | HCID 23461675 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 70575136 | HCID 70575136 | 73.8% |
Reaction Steps
Reaction between 4-acetylamino-5-bromo-2-methoxybenzoyl chloride (prepared from 2.1 g. of corresponding acid and thionyl chloride), N-amino-N'-methyl piperazine (0.85 g.) and triethylamine (2 ml.) in toluene followed by alkaline hydrolysis as described in Example 20 gave 4-amino-5-bromo-2-methoxy-N-[4-methyl-1-piperazinyl]-benzamide hemihydrate (1.78 g., 68%) m.p. 174°-6° (ex-chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04267175 |
| Source dataset | uspto-grants-1981_05 |
| ORD ID | ord-d12c960b2dee49b7aab2c339b209ce34 |
| Source note | uspto-grants-1981_05 |