p-Toluenesulfonic acid → HCID 12837909, compound

Participants

Reaction Steps

A solution of 1,3-dihydro-3-oxo-2H-isoindole-1-acetic acid (described by F. M. Rowe et al., J. Chem. Soc., 1098 (1936) 130 g, 0.682 mol) in methanol (1300 ml) containing 6.5 g of p-toluenesulfonic acid was refluxed with stirring for 3.5 hr. Most of the methanol was evaporated and the residue was dissolved in chloroform. The solution was washed with 5% aqueous sodium bicarbonate and water, dried and evaporated. The residue (125 g) was crystallized from isopropanol to give methyl 1,3-dihydro-3-oxo-2H-isoindole-1-acetate, mp 136°-138° C.

Provenance & Evidence